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Projecten 2015

In 2015 door het Reumafonds gefinancierd

Artrose

Klinisch

Diagnostic criteria for early osteoarthritis of hip and knee
Projectleider: prof. dr. S.M.A. Bierma-Zeinstra
Instelling: Erasmus MC, Rotterdam
Looptijd: 2015-2017

Is low dose radiotherapy an effective treatment option for patients with established hand osteoarthritis? A proof-of-concept study
Projectleider: dr. C.H.M. van den Ende
Instelling: Sint Maartenskliniek, Nijmegen
Looptijd: 2015-2016

Objective assessment of functional knee joint stability in patients with knee osteoarthritis
Projectleider: prof. dr. ir. J. Harlaar
Instelling: VUmc, Amsterdam
Looptijd: 2015-2018 

Stratified care in knee osteoarthritis: a pilot-study to evaluate feasibility of tailored interventions in primary care
Projectleider: prof. dr. J. Dekker
Instelling: VUmc, Amsterdam
Looptijd: 2015-2016

The diagnostic imaging work-up of synovitis in knee osteoarthritis with a novel non-contrast MRI technique or ultrasound
Projectleider: dr. E.H.G. Oei
Instelling: Erasmus MC, Rotterdam
Looptijd: 2016-2017

Translationeel

Low electric current to prevent pin-tract infections, reducing the use of antibiotics, increasing convenience for patients treated with knee joint distraction
Projectleider: prof. dr. F.J.P. Lafeber
Instelling: UMC Utrecht
Looptijd: 2016

Pharmacological attenuation of thyroid hormone signalling: An evidence-based treatment option for osteoarthritis
Projectleider: dr. I. Meulenbelt
Instelling: LUMC, Leiden
Looptijd: 2016-2019

Towards a BMP-7 peptide-based OA treatment
Projectleider: dr. T.J.M. Welting
Instelling: Maastricht UMC+
Looptijd: 2016-2019

Fundamenteel

Inflammation-induced SOCS3 leads to deleterious chondrocyte behaviour by altering TGF-β signalling, resulting in progressive cartilage damage in osteoarthritis
Projectleider: dr. E.N. Blaney Davidson
Instelling: Radboudumc, Nijmegen
Looptijd: 2016-2019

Reumatoïde artritis

Klinisch

The value of MRI of the foot in the early identification of rheumatoid arthritis in addition to MRI of the hand and wrist
Projectleider: dr. M. Reijnierse
Instelling: LUMC, Leiden
Looptijd: 2015- 2016

Translationeel

Targeted photoimmunotherapy against synovial fibroblasts to treat inflamed joints in patients with rheumatoid arthritis
Projectleider: dr. M. Buitinga
Instelling: Radboudumc, Nijmegen
Looptijd: 2016-2018

Reducing heterogeneity: Towards a better under­ standing of RA through advanced cluster analysis
Projectleider: prof. dr. T.W.J. Huizinga
Instelling: LUMC, Leiden
Looptijd: 2016-2018

Fundamenteel

Chemical approaches to study the role of protein carbamylation in rheumatic disease
Projectleider: dr. S. I. van Kasteren
Instelling: LUMC, Leiden
Looptijd: 2016-2017

Towards understanding the B cell immune response against citrullinated antigens in rheumatoid arthritis
Projectleider: dr. H.U. Scherer
Instelling: LUMC, Leiden
Looptijd: 2016-2019

Mer: the double-edged sword in treatment of rheumatoid arthritis
Projectleider: dr. A. van de Loo
Instelling: Radboudumc, Nijmegen
Looptijd: 2016-2019

Determining the potential of targeting class 3 semaphorins in the treatment of rheumatoid arthritis
Projectleider: dr. K. A. Reedquist
Instelling: UMC Utrecht
Looptijd: 2016-2017

Circulating nucleic acids in rheumatoid arthritis: from biomarkers to pathophysiology
Projectleider: prof. dr. G.J.M. Pruijn
Instelling: Radboudumc, Nijmegen
Looptijd: 2016-2017

Definition of human T cell receptors for immune regulation: towards a 'TcR transduced Treg therapy (TTT)' for RA
Projectleider: prof. dr. Willem van Eden
Instelling: Universiteit Utrecht, faculteit Diergeneeskunde
Looptijd: 2016-2017

Unravelling the molecular mechanism of long-lasting epigenetic changes induced by vitamin D in Th17 cells of patients with rheumatoid arthritis and psoriatic arthritis
Projectleider: dr. E. Lubberts
Instelling: Erasmus MC, Rotterdam
Looptijd: 2016-2017

Syndroom van Sjögren

Klinisch

REgistry of Sjögren's syndrome in University Medical Center Groningen: a LongiTudinal study (RESULT). The parotid connection
Projectleider: prof. dr. H. Bootsma
Instelling: UMC Groningen
Looptijd: 2015-2017

Translationeel

Defective human salivary gland stem cells: the cause of primary Sjögren's syndrome?
Projectleider: prof. dr. F.G.M. Kroese
Instelling: UMC Groningen
Looptijd: 2016-2018

Fundamenteel

Antigenic specificities and genetic damage of expanded B cells and B-cell lymphomas in Sjögren's syndrome
Projectleider: dr. R.J. Bende
Instelling: AMC Amsterdam
Looptijd: 2016-2018

Spondyloartritis

Fundamenteel

The contribution of non-canonical NF-kB signalling in endothelial cells to pathological bone formation in spondyloarthritis
Projectleider: dr. S. W. Tas
Instelling: AMC/UvA, Amsterdam
Looptijd: 2016-2019

Systemische lupus erythematodes (SLE)

Klinisch

Unraveling incomplete lupus - search for prognostic factors for progression to systemic lupus erythematosus
Projectleider: dr. K. de Leeuw
Instelling: UMC Groningen
Looptijd: 2015-2018

Fundamenteel

Using engineered anti-C1q autoantibodies to specifically inhibit immune complex mediated tissue damage
Projectleider: dr. L.A. Trouw
Instelling: LUMC, Leiden
Looptijd: 2016-2017

Overige

Klinisch

A multicentre randomized placebo controlled treatment study of leflunomide in polymyalgia rheumatica
Projectleider: dr. E. Brouwer
Instelling: UMC Groningen
Looptijd: 2015-2017

Rheumatologist's implicit and explicit medication attitudes as possible target for improving medication adherence in patients using conventional disease modifying anti-rheumatic drugs
Projectleider: dr. B.J.F. van den Bemt
Instelling: Sint Maartenskliniek, Nijmegen
Looptijd: 2015-2016

Translationeel

Testing the therapeutic potential of Semaphorin4A as modulator of Th17 polarization in systemic sclerosis
Projectleider: dr. S. Garcia Perez
Instelling: UMC Utrecht
Looptijd: 2016

A novel disease model for giant cell arteritis: the antibody-independent role of B cells in the pathogenesis of giant cell arteritis
Projectleider: dr. M. Sandovici
Instelling: UMC Groningen
Looptijd: 2016-2019

Genetic studies in sternocostoclavicular hyperostosis: unravelling the pathophysiology of a rare auto-inflammatory bone disease
Projectleider: dr. N.A.T. Hamdy
Instelling: LUMC, Leiden
Looptijd: 2016-2017

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